The study suggests that magnolia bark protects kidneys from oxidative stress, maintains the oxidative capacity of cells, and stabilizes the structure of epithelial cells during cancer treatment. What you eat can have a big effect on inflammation in your body. Spray the leaves and petioles with an aqueous solution of copper fungicide. The side effects were reported only in a single case, and the study did not explain their cause in relation to the treatment. In our present study, a novel finding was that PGC-1 was increased by more than 10-folds after BL153 treatment. Effects of chronic treatment with honokiol in spontaneously hypertensive rats. In contrast, those who chewed on normal mints showed only a 4% drop in bad odor-causing bacteria. In lab tests using rats fed a high-fat diet, magnolol and honokiol reduced fat and protected against insulin resistance. People who use benzodiazepine may use magnolia bark as a natural sedative. Magnolia Bark Extract Uses, Benefits & Dosage - Drugs.com Tweak prevents Tnf-Alpha-induced insulin resistance through Pp2a activation in human adipocytes. Hara K, Tobe K, Okada T, et al. The extract of the bark of Magnolia trees (Magnolia officianalis) has been used for some 1,000 years in traditional Chinese and Japanese medicine for treatment of maladies ranging from asthma to depression to headaches to muscle pain. Avoid keeping the ground around the magnolia constantly moist. Its important to note that the exact mechanisms through which the isolated compounds contribute to these effects are still being investigated. Agosta C, Atlante M, Benvenuti C. Randomized controlled study on clinical efficacy of isoflavones plus Lactobacillus sporogenes, associated or not with a natural anxiolytic agent in menopause. In traditional Chinese medicine, magnolia bark is considered to have antipyretic, analgesic, sedative, constipating, anti-asthmatic, cardioprotective, vasoprotective, or antibacterial properties. I had some severe pains in my kidneys and started taking this product before bed each night. Kim YJ, Choi MS, Cha BY, et al. 2011 Feb;63(1):11-7. n = 5; *P < 0.05 versus LFD group; # Does dihydrohonokiol, a potent anxiolytic compound, result in the development of benzodiazepine-like side effects? Honokiol also showed antitumor and antiangiogenic effects(23)(24)(25) in leukemia(26), lung(27)(28), bladder(29), prostate(30), melanoma(31)(32), breast(33), glioblastoma(34), neuroblastoma(35), and oral cancer(36) cells lines. The women experienced significant improvements in insomnia, anxiety, mood, and irritability (31). Especially for lowering stress, studies observed that consuming 500 mg of magnolia and Phellodendron bark extract per day greatly reduced cortisol levels. Tell your doctor about any supplements you're taking, even if they're natural. Anti-bacterial: helps against acne and itching. Renal pathology was examined by using hematoxylin and eosin staining (b), and the arrows indicated glomerular enlargement and renal tubular epithelium damage. Anti-inflammatory: helps reduce redness, irritation, and soothes the skin. PMID: 3413728. Furthermore, this research concluded that magnolia bark extract has two main components, magnolol and honokiol, responsible for this inhibitory effect against bacteria in the mouth. Antitumor activity also occurred via MMP9 inhibition through the NF-kB pathway in breast cancer cells(19) and through AMPK activation in colorectal cancer cells(18). Spoto B, Mattace-Raso F, Sijbrands E, et al. Last medically reviewed on April 7, 2020, Cissus quadrangularis is a plant that has long been used as a natural remedy to treat a wide variety of ailments. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. As shown in Figure 2, kidney weight to tibia length ratio was increased in HFD-fed mice compared with low fat diet- (LFD-) fed mice. Researchers also noticed that magnolia extract could have a strong anti-inflammatory effect. 6 Benefits and Side Effects of Relora (Sleep, Weight Loss), 4 Benefits of Phellodendron Bark Extract (for Dopamine, Skin? We used Image Quant 5.2 to analyze western blotting. Epub 2017 Aug 17. Kidney weight to tibia length ratio (Figure 2(a)) and kidney hematoxylin and eosin (H&E) staining were undertaken to evaluate the protective effects of BL153 on obesity-induced kidney structure changes. PMID: 21311416. Excess stress is a common problem. Powdery mildew is a fungal disease that affects magnolia leaves. Some studies have prescribed concentrated magnolia bark extracts for up to 1 year without any observations of adverse effects (1). Fatigue. Sweet Magnolia: Tree Bark Extract Fights Bad Breath And Tooth Decay. ScienceDaily. A New Rabbit Hole: Magnolia Bark Extract - Cure Parkinson's Magnolias have always been highly sought-after trees in the yard. Our scientists pursue every aspect of cancer researchfrom exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Magnolol induces apoptosis in MCF-7 human breast cancer cells through G2/M phase arrest and caspase-independent pathway. Weisinger JR, Kempson RL, Eldridge FL, Swenson RS. Careers, Unable to load your collection due to an error. Does Magnolia Bark affect Thyroid function? In murine models, honokiol enhanced low-dose docetaxel treatment against prostate cancer growth and bone metastasis(37), and reduced breast tumor growth biomarkers(48). Honokiol, a natural plant product, inhibits the bone metastatic growth of human prostate cancer cells. Another candidate molecule is HK II. AltMed-REAX for the patient: "Magnolia bark. This article reviews what it is, its best uses, potential benefits, and side, Suma root has many medicinal uses in folk medicine, but scientific evidence supporting its purported benefits is lacking. Therefore, magnolia bark could be used as a remedy for insomnia or simply to promote better sleep overall. Repeat the spraying in two weeks. Here is a closer look at some of the potential benefits of magnolia bark. Diabetes. Avoid using magnolia during pregnancy. Biphenyl-type neolignans from, Shih HC, Hwang TL, Chen HC, et al. Polyphenols are highly valued for their antioxidant levels and believed to offer many health benefits. 2017 Nov;43(6):760-769. doi: 10.1002/biof.1385. Magnolia Bark extract is a great method for getting rid of bad breath as research shows it can kill bacteria that may cause a bad odor in the mouth. BL153 upregulated renal PGC-1 and NQO1 expression. Try to keep your magnolia tree undamaged. Further, magnolia bark has a well-established safety profile for short-term use. Given the contradictory nature of studies and the available information, more human studies and clinical trials are required to establish the effects of magnolia bark on kidneys. BL153 ameliorated obesity-induced renal inflammation. Water the magnolia with liquid fertilizer to give it the strength to fight the disease. The pathogen enters the tree through damage (wounds, cracks, etc.). Also black necroses appear in the most severely affected places. Biochem Pharmacol. Here are 15 effective ways to relieve stress and anxiety. PMID: 18426577; PMCID: PMC2359758. biloba Rehder & E.H.Wilson (Magnoliaceae) and it is indicated in CHM for conditions that include vomiting and diarrhea, abdominal disorders, and cough ( CPC, 2010 ). Collect the fallen leaves from underneath the magnolia. Afterward, feed the tree with a multi-purpose fertilizer. Magnolia bark may potentiate the effect of anti-diabetic drugs. Bethesda, MD 20894, Web Policies The short-term side effects of magnolia bark are generally mild but can range from headaches, upset stomachs, and dizziness to fatigue, diarrhea, nausea, and dry mouth. 2005 Apr;71(4):338-43. doi: 10.1055/s-2005-864100. BL153 upregulated renal HK II expression. Male C57/BL6/J mice at 8 weeks of age were purchased from the Jackson Laboratory and housed in the University of Louisville Research Resources Center at 22C with a 12-hour light/dark cycle. 2010 Sep 16;15(9):6452-65. doi: 10.3390/molecules15096452. Severe canker infections can cause plant death. As a potential P-glycoprotein inhibitor, constituents of magnolia bark extract may reduce multidrug resistance in cancer cells via P-gp downregulation(42)(43). Introducing the aspect of non-pharmacological treatment of diabetes . Can Magnolia Bark extract be used for getting rid of Bad Breath? However, young trees can be severely damaged if the disease is noticed too late. I bought this item because I read a scientific study which said that magnolia bark extract has been able to stop kidney disease from progressing. Vazquez-Carballo A, Ceperuelo-Mallafre V, Chacon MR, et al. Preliminary clinical studies suggest benefits with magnolia for vasomotor symptoms(38), weight management(39), and oral health(40). Honokiol is a potent scavenger of superoxide and peroxyl radicals. Sesti G, Succurro E, Arturi F, et al. Recently, inflammation and oxidative stress have emerged to be involved in provoking insulin resistance in obesity-associated kidney damage [6, 7]. All rights reserved. This Web site is not to be used as a substitute for medical advice, diagnosis or treatment of any health condition or problem. The lipid peroxidation by-product 4-hydroxy-2-nonenal (4-HNE) induces insulin resistance in skeletal muscle through both carbonyl and oxidative stress. Weisinger RS, Stanley TK, Begg DP, Weisinger HS, Spark KJ, Jois M. Angiotensin converting enzyme inhibition lowers body weight and improves glucose tolerance in C57BL/6J mice maintained on a high fat diet. Int J Mol Sci. Taking magnolia bark along with drugs that promote sleep or treat anxiety, such as sedatives, sleep medications, and barbiturates, may cause drowsiness. Suppression of, Semple RK, Crowley VC, Sewter CP, et al. If you use magnolia bark extract directly on the skin, the best way is with a solubilizer such as Pentylene Glycol Natural. Tear off leaves that have more than four or five spots on them. Additionally, kidney histopathological alterations in HFD-fed mice were mild at the end of experiment, such as glomerular enlargement and renal tubular epithelium damage. New botanical drug, HL tablet, reduces hepatic fat as measured by magnetic resonance spectroscopy in patients with nonalcoholic fatty liver disease: A placebo-controlled, randomized, phase II trial. Tell patients to discontinue magnolia at least 2 weeks before elective surgical procedures. After those membranes were washed with Tris-buffered saline (pH 7.2) containing 0.05% Tween 20 and incubated with the appropriate secondary antibodies. Magnolia bark is a staple of traditional Chinese medicine and is used today for a variety of potential health benefits ranging from the treatment of depression and insomnia to improving oral health. Huang HC, Hsieh WY, Niu YL, Chang TM. Woodbury A, Yu SP, Wei L, Garca P. Neuro-modulating effects of honokiol: a review. Magnolol demonstrated activity against a variety of cancers, including bladder(10)(11)(12), prostate(13)(14)(15)(16), colorectal(17)(18), breast(19)(20), and lung(21)(22) cancers. However, the supplement used in these studies contained compounds other than magnolia bark. This article outlines an anti-inflammatory diet plan that is based on science. A 2019 review study found that honokiol has shown potential to prevent tumor growth in the brain, breast, colon, liver, and skin, among other organs (17). Sarrica A, Kirika N, Romeo M, Salmona M, Diomede L. Safety and Toxicology of Magnolol and Honokiol. Throw away all this debris as far away from the garden as possible. They are used in cosmetic and weight loss products, and their use as anti-cancer, antioxidative, and anti-inflammatory agents is being studied. Some researchers believe that these effects are due to honokiol, a natural compound in the bark. Consistent with these reports, our present study found that inflammatory markers, like TNF- and PAI-1, and oxidative stress markers, like 3-NT and 4-HNE, were elevated in HFD-fed mice, accompanied by insulin resistance as we reported recently (Sun et al., unpublished paper). EDRF-release and Ca+(+)-channel blockade by magnolol, an antiplatelet agent isolated from Chinese herb. 2005 - 2023 WebMD LLC, an Internet Brands company. Also, it creates effects similar to the benzodiazepine class of drugs which can result in dependency. Can Magnolia Bark extract be used for Acne? However, Zhang et al. Magnolol suppresses hypoxia-induced angiogenesis via inhibition of HIF-1alpha/VEGF signaling pathway in human bladder cancer cells. Memorial Sloan Kettering Cancer Center makes no warranties nor express or implied representations whatsoever regarding the accuracy, completeness, timeliness, comparative or controversial nature, or usefulness of any information contained or referenced on this Web site. Up till now, more than 250 kinds of ingredients have been isolated from the cones, bark, and leaves of the Magnolia genus, such as magnolol, honokiol, 4-O-methylhonokiol, and obovatol [10]. Magnolia bark is a powerful supplement prepared from the bark, leaves, and flowers of the houpo magnolia tree. Not enough is known to rate the safety of topical supplements with Magnolia Bark applied to the skin. ), digestive problems, constipation, diarrhea, Possible kidney damage after long-term use. They are not round, but angular or irregular in shape. Therapeutic targeting of Krppel-like factor 4 abrogates microglial activation. Lee, Y.J. Magnolia bark is considered a safe supplement for human consumption. PMID: 22771461. Super CitriMax (HCA-SX) attenuates increases in oxidative stress, inflammation, insulin resistance, and body weight in developing obese Zucker rats. If the infestation is on the branch, cut it off below the affected area. Taken together, the present study declares that BL153 administration may be a novel approach for renoprotection in obesity individuals. The beneficial effects of magnolol on learning and memory abilities were reported to be associated with superoxide dismutase (SOD) restoration in a scopolamine-induced mouse model [26]. Magnolia Extract (BL153) Ameliorates Kidney Damage in a High Fat Diet The bark then undergoes a process of drying and boiling before its infused into a tincture for oral consumption. Throw it all in the trash or burn it. The bark is particularly rich in two neolignans that are believed to be responsible for its medicinal properties magnolol and honokiol (1, 2). Additional studies and research is required to establish a relationship between thyroid function and magnolia bark usage if any. MG132 is a peptide aldehyde proteasome inhibitor and exerts its therapeutic effects by reducing the degradation of ubiquitin-conjugated proteins such as nuclear-factor-E2-related-factor-2 (Nrf2), an important transcription factor regulating cellular defenses against reactive oxygen species, through inhibiting activity of the subunits of the core particle of 26S proteasome [38]. Tell your healthcare providers about any dietary supplements youre taking, such as herbs, vitamins, minerals, and natural or home remedies. Jiang S, Zhang L-F, Zhang H-W, et al. Accumulating evidence demonstrated that obesity is a risk factor for renal structural and functional changes, leading to the end-stage renal disease which imposes a heavy economic burden on the community. Teng CM, Chen CC, Ko FN, Lee LG, Huang TF, Chen YP, Hsu HY. Honokiol suppresses lung tumorigenesis by targeting EGFR and its downstream effectors. Garrison R, Chambliss WG. Magnolia bark extract can be found at most supplement retailers. 19 Magnolia Bark Medicinal Uses (Kidney Failure Side Effects?) Always use a sterile pruning tool. A product that contains myclobutanil works best. Amazon.com: Customer reviews: Genesis Today, Magnolia Bark Supplement Magnolia barks effects on sleep appear to be closely connected to the activity of the GABA(A) receptors in the central nervous system. Prog Neuropsychopharmacol Biol Psychiatry. Pathogens settle on the leaves and begin to destroy them. Control groups were given same volume of ddH2O with 0.05% ethanol. Magnolia bark extract is readily available in pill form. Similarly, increased kidney 3-NT and 4-HNE expression caused by HFD feeding were all prevented by BL153 treatment (Figure 4). Int J Dent Hyg. Insulin-induced hexokinase II expression is reduced in obesity and NIDDM. 2017 Mar.;18(3):194-214. Seizures or coma in severe cases. Magnolia might have CNS depressant and antiplatelet effects (11946,11952,18273). P < 0.05 versus HFD group. Biol Pharm Bull. One of the important jobs of the kidneys is to clean the blood. They also discovered that cortisol levels in the treatment group remained low in the evening and at bedtime. Magnolias are also susceptible to nectria canker, a bacterial infection that causes sunken, discolored areas of bark. In THP-1 cells, magnolol and honokiol reduced inflammatory TNF- and IL-8 production induced by Propionibacterium acnes (3). They enter the tree through wounds or cracks in the bark. Chronic kidney failure is a significant problem in modern society. Cui W, Bai Y, Miao X, et al. In this study, we demonstrated that NQO1, but not SOD2 (data not shown), was significantly increased by BL153 administration (Figure 5(b)). Clean the wound of dead tissue. The leaf may darken or turn brownish green. The leaves and flowers from the tree are sometimes used as well. Magnolol affects expression of IGF-1 and associated binding proteins in human prostate cancer cells in vitro. The ethanol extract of M. officinalis (BL153) was analyzed by HPLC to ensure mainly that it is containing 14.8% of 4-O-methylhonokiol, 14.2% of honokiol, and 12.0% of magnolol, which were in agreement with previously published data [42]. Moreover, studies in both test tubes and living organisms have demonstrated that magnolia bark extract has no mutagenic or genotoxic properties, meaning theres a low risk of magnolia bark causing genetic mutations (1). PMID: 28271656; PMCID: PMC5365644. A similar study in more than 600 menopausal women found that consuming a magnolia bark supplement daily for 12 weeks relieved symptoms of insomnia, irritability, and anxiety (32). (PDF) Magnolia Extract (BL153) Ameliorates Kidney Damage - ResearchGate 1981 Aug;70(8):951-2. doi: 10.1002/jps.2600700833. Additionally, a test-tube study found that magnolol inhibited the growth of lung cancer cells (21, 22). Chiang J, Shen Y-C, Wang Y-H, et al. Cui W, Maimaitiyiming H, Qi X, Norman H, Wang S. Thrombospondin 1 mediates renal dysfunction in a mouse model of high-fat diet-induced obesity. Our data demonstrated for the first time that these alterations could be reversed by BL153 administration. Magnolia officinalis is a flowering herb that has been used in traditional Chinese medicine to treat anxiety, depression, stress, nervousness, and sleep-related problems. Contact dermatitis: In 4 patients following application of magnolia extract-containing cosmetics(44)(45). Furthermore, it is frequently associated with other inflammatory disease such as diabetes and cardiovascular disorders. Review Article Herbal medicines and chronic kidney disease PMID: 15856410. found that long-term supplementation of honokiol and magnolol attenuated body fat accumulation, insulin resistance, and adipose inflammation [17]. Enhanced Nrf2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice. This not only includes brain disorders like Alzheimers disease but also conditions like stress, anxiety, mood disorders, and depression (23). The causative relationship between obesity and proteinuria was first reported in 1974 [1]. Statistical analysis was performed with Origin 7.5 Laboratory data analysis and graphing software. If you decide to supplement with magnolia bark, carefully follow the manufacturers instructions regarding how much to take and how often. PMID: 20877235; PMCID: PMC6257695. Munroe ME, Businga TR, Kline JN, Bishop GA. Anti-inflammatory effects of the neurotransmitter agonist Honokiol in a mouse model of allergic asthma. This result is significant as high cortisol levels have been strongly linked to high blood pressure. PMID: 7310672. Is Garcinia Cambogia Safe for Weight Loss? Importantly, BL153 treatment attenuated obesity caused renal inflammation and oxidative stress, which was likely due to the ability of BL153 to increase PGC-1 and HK II expression in kidney. Avoid overwatering the magnolia and allow the soil to dry out a little between waterings. Regulation of Mucin 1 and multidrug resistance protein 1 by honokiol enhances the efficacy of doxorubicin-mediated growth suppression in mammary carcinoma cells. Therapeutic applications of compounds in the Magnolia family. Magnolia bark extract Magnolol Houpu magnolia Hou Po Jump to: For Patients & Caregivers For Healthcare Professionals For Patients & Caregivers Tell your healthcare providers about any dietary supplements you're taking, such as herbs, vitamins, minerals, and natural or home remedies. Suma Root: Nutrients, Benefits, Downsides, and More, Sorrel: Nutrients, Benefits, Downsides, and Recipes, 15 Impressive Herbs with Antiviral Activity, Anti-Inflammatory Diet 101: How to Reduce Inflammation Naturally, 13 of the Most Anti-Inflammatory Foods You Can Eat, The Signs and Symptoms of Too Much Stress. Skin whitener: helps fade dark spots and gives the appearance of an even complexion. It is also used to regulate gastrointestinal motility(50) and is found in herbal formulas such as Ma Zi Ren Wan. Chronic kidney disease - Symptoms and causes - Mayo Clinic Today, magnolia bark extract is readily available in pill form. Data in humans are limited. Our website services, content, and products are for informational purposes only. This article reviews the science-supported benefits and side effects of magnolia bark. Clean the wound of dead wood and wash it with alcohol. "Magnoliae Officinalis Cortex" [Hou Po ()] is the dried stem bark, root bark, or branch bark of Magnolia officinalis Rehder & E.H.Wilson or M. officinalis var. It is also used to regulate gastrointestinal motility and is found in herbal formulas such as Ma Zi Ren Wan. This is a rather serious disease that can lead to the death of the tree if left untreated. Call us at 833-347-1665 to make an appointment. All experiments involving mice conformed to the National Institutes of Health Guide for the Care and Use of Laboratory Animals and were approved by the University of Louisville Institutional Animal Care and Use Committee. The mixture also increased serotonin metabolite levels in the frontal cortex, striatum, and nucleus accumbens at 40 mg/kg. Neuroprotective effects of honokiol: from chemistry to medicine. Therefore, as long as magnolia bark is used responsibly, there do not appear to be many risks associated with its use. Furthermore, its best to speak with your healthcare provider before taking magnolia bark supplements, especially if youre currently using other supplements or medications. The authors declare that they have no conflict of interests. Boil 3 cups of water in a vessel and add about 2 cups of dry magnolia petals. A proposed mechanism by which BL153 attenuates kidney damage during obesity is illustrated.
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